Nattokinase is a potent enzyme derived from natto, a traditional Japanese fermented soybean dish. Natto, a fermented cheese-like food, has been a staple in Japanese cuisine for over thousands of years. It consists of soybeans that are cooked and fermented with the action of the bacterium Bacillus subtilis.
Renowned for its remarkable health benefits, nattokinase has recently garnered attention for its potential to support cardiovascular health. This potential is attributed to nattokinase’s ability to break down fibrin, a protein involved in blood clot formation. By promoting fibrinolysis, nattokinase may help dissolve blood clots and maintain healthy blood flow (1). Another mechanism associated with its potential to support cardiovascular health is by blocking thromboxane formation (2).
Due to its outstanding potential in improving blood flow and supporting healthy blood pressure levels, nattokinase is increasingly recognized as a natural supplement forcardiovascular wellness.
Additionally, nattokinase has gained increasing attention from the scientific community regarding Alzheimer’s disease and oncology.
Specifically, nattokinase:
May impact amyloid plaque accumulation characteristic ofAlzheimer’s disease(3)
Degrades the major extracellular matrix component fibronectin while alsoinhibiting tumor-associated fibroblasts(CAFs), resulting in decreased tumor stiffness, enhanced perfusion, and alleviation of hypoxia. (4)
Exhibitsanti-angiogenesiseffects by suppressing VEGF, CD31, FOXM1, CD44 and vimentin (5, 6, 7).
Finally, nattokinase may also support the human body in breaking down unwanted wastes in the blood and undigested proteins in the gut.
Overall, Nattokinase offers a holistic approach to health, addressing various aspects from cardiovascular well-being to brain health, gut health and beyond. Furthermore, it represents a potentially outstanding tool in oncology.
*The statements in this section have not been evaluated by the FDA or EFSA.
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